Highly regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 5th Edition, provides a unique, integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps both under...

Highly regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 5th Edition, provides a unique, integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps both undergraduate and graduate students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets.

• Chapters are integrated into sections that focus onorgan systems and therapeutic areasof highest importance.

-Hundreds of clear, concise illustrationshighlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms,and dozens of popular and practical drug summary tablesoffer quick access to essential information.

• All chapters have beencomprehensively updated, including recently discovered mechanisms and recently approved drugs.

-Content updates, new chapters, new figures, and new casesadded to key areas such as endophenotypes as drug targets, immunotherapy, protein-based therapeutics, oligonucleotide-based therapies, and gene therapy and gene editing.

• Dr. David Golan’s pathophysiologic approach, pioneered at Harvard,mirrors critical thinking and is ideal for integrated, systems-based courses.